Monthly Archives: January 2015

David W. Bates, M.D., M.Sc.

Harvard Medical School 11-06-16David W. Bates, M.D., M.Sc.
Chief Innovation Officer, Brigham and Women’s Hospital

Dr. Bates is an internationally renowned expert in using information technology to improve clinical decision-making, patient safety, quality-of-care, cost-effectiveness, and outcomes assessment in medical practice.  A practicing general internist, Dr. Bates is Chief Quality Officer at Brigham and Women’s Hospital in Boston where he is also Chief of the Division of General Internal Medicine.  He is a Professor of Medicine at Harvard Medical School, and a Professor of Health Policy and Management at the Harvard School of Public Health, where he co-directs the Program in Clinical Effectiveness. He also serves as Medical Director of Clinical and Quality Analysis for Partners HealthCare.

Dr. Bates is a graduate of Stanford University, and the Johns Hopkins School of Medicine. He began his fellowship in general internal medicine at Brigham and Women’s Hospital in 1988, and he received an M.Sc. in Health Policy and Management from the Harvard School of Public Health in 1990.  He has been elected to the Institute of Medicine, the American Society for Clinical Investigation, the Association of American Physicians and the American College of Medical Informatics, and is past chairman of the Board of the American Medical Informatics Association. He serves as external program lead for research in the World Health Organization’s Global Alliance for Patient Safety.  He is the president of the International Society for Quality in Healthcare (ISQua).  He is the editor of the Journal of Patient Safety.  Dr. Bates’ special research interests include clinical decision-making and affecting physician-decision-making, particularly using computerized interventions; quality of care and cost-effectiveness and medical practice; and outcome assessment.  He has published over 700 peer-reviewed papers.

Richard S. Blumberg, M.D.

Richard S. Blumberg, MDDr. Richard S. Blumberg trained in internal medicine (The New York Hospital, 1982), infectious diseases (Massachusetts General Hospital, 1986) and gastroenterology and hepatology (Brigham and Women’s Hospital 1989). He is currently Senior Physician in Medicine and Gastroenterology at Brigham and Women’s Hospital (BWH) where he holds the position of Division Chief of Gastroenterology, Hepatology and Endoscopy, is a Professor of Medicine at Harvard Medical School, co-Director of the Harvard Digestive Diseases Center and Chair of the Brigham Research Institute. In addition, Dr. Blumberg serves on the Executive Advisory Committee of the Department of Medicine and has served as a member of the Immunology Sciences Study Section of the NIAID, a member on the National Commission of Digestive Diseases of the NIDDK, scientific consultant to the Human Microbiome Project (NHGRI), a member of the Vaccine Branch External Advisory Board (NCI), Chair of the External Scientific Consultants for the Intestinal Stem Cell Consortium Initiative (NIDDK), and a member of the Board of Scientific of Scientific Councilors (NIAID). Dr. Blumberg has served as the Chair of the National Scientific Advisory Committee of the Crohn’s and Colitis of America (2002-2005) and was former President of the Society for Mucosal Immunology (2007-2009). Dr. Blumberg is an elected member of the American Association of Clinical Investigation and the Association of American Physicians and the recipient of a MERIT award from the NIH (2005), the William Beaumont Prize from the American Gastroenterological Association (2012), the Distinguished Scientific Achievement Award from the Crohn’s and Colitis Foundation of America (2012) and Lifetime Achievement Award from the Society of Mucosal Immunology (2015). He has been an NIH funded investigator since 1989 whose research program focuses on mucosal immunology. He was the Scientific Founder of Syntonix Pharmaceuticals that developed long acting therapeutic agents recently approved by the FDA for the treatment of hemophilia and has long standing research interests that focus on mucosal immunology which are specifically directed at studying the roles of CD1d-NKT cells, the unfolded protein response, CEACAM1 and FcRn.

Kitty (Frances Catherine) O’Hare, M.D.

Kitty (Frances Catherine) O’Hare, M.D., F.A.A.P., Assistant Professor of Medicine, Harvard Medical School

Dr. Kitty O’Hare received her Bachelor of Arts Honors degree in Biology from the College of the Holy Cross in Worcester, Massachusetts and her medical degree from the Perelman School of Medicine at the University of Pennsylvania.  She completed her internship and residency in the inaugural class of internal medicine- pediatrics at the Hospital of the University of Pennsylvania and the Children’s Hospital of Philadelphia. After completing her training in 2008, Dr. O’Hare was recruited to the Division of General Pediatrics at Boston Children’s Hospital.  Upon arriving in Boston, she also joined the Department of Medicine at Brigham & Women’s Hospital and was appointed as Instructor at Harvard Medical School.  In 2014, Dr. O’Hare was promoted to Assistant Professor of Medicine at Harvard Medical School.

Currently Dr. O’Hare serves as the Director of Transition Medicine for Primary Care at Boston Children’s Hospital.  She provides outpatient transition consultations and is a co-founder of the Weitzman Family BRIDGES Young Adult Program.  In addition, Dr. O’Hare is a staff physician at Brigham & Women’s Family Care Associates where she provides primary care to children and adults.

Dr. O’Hare is an Innovations Fellow at the Harvard Medical School Center for Primary Care for the 2014-15 academic year. She serves as a site director for the Center’s Academic Innovations Collaborative and she is part of the Center’s Working Group on Primary Care Curriculum. In 2013 Dr. O’Hare received the John J.W. Fangman Mentoring Award from the Brigham & Women’s/Boston Children’s Hospital Internal Medicine-Pediatrics Residency Program.

Dr. O’Hare is a Fellow of the American Academy of Pediatrics; from 2012-14 she served as the chair of the Committee on Disabilities for the Massachusetts Chapter.  Since 2012, Dr. O’Hare has been a member of the Massachusetts Child Health Quality Coalition.  As part of that group’s Confidentiality Task Force, she helped to develop a statewide manual for clinicians and families entitled, “Communication Matters: a guide for sharing information about a child’s care.”  Dr. O’Hare is also an advisor to the National Center for Health Insurance and Financing for Children and Youth with Special Health Care Needs.

Dr. O’Hare has authored several articles on young adult transition care.  Her most recent publication is a chapter on the care of youth with cognitive delays, within the text, “Are Your Pediatric Patients Ready for Adult Health Care?  What to Do and How to Do It” edited by Laurie Fishman.

Dr. O’Hare’s primary teaching interests include transitions from pediatric to adult care, management of children with special health care needs, and primary care quality improvement.  She is the co-director of the Brigham & Women’s/Boston Children’s Hospital Transition to Adult Care Conference.

Marc Alan Pfeffer, M.D., Ph.D.

Marc Pfeffer 2013
Dzau Professor of Medicine, Harvard Medical School
Senior Physician, Cardiovascular Division, Brigham and Women’s Hospital

Dr. Marc Pfeffer is the Dzau Professor of Medicine at Harvard Medical School, and Senior Physician in the Cardiovascular Division at the Brigham and Women’s Hospital in Boston.  A noted researcher, Dr. Pfeffer, along with his late wife, Dr. Janice Pfeffer, and Eugene Braunwald MD, is credited with introducing the concept that angiotensin-converting enzyme inhibitors (ACEIs) could attenuate adverse ventricular remodelling following myocardial infarction and that this use would result in a prolongation of survival and other clinical benefits.  Since this initial discovery, he has had a principal role in several practice-changing clinical trials such as SAVE, CARE, HEART, VALIANT, CHARM, PEACE, ARISE, TREAT, ALTITUDE and RED-HF.  He is currently a leading investigator in TOPCAT and ELIXA, trials in patients with heart failure with preserved ejection fraction and diabetes, respectively.

Dr. Pfeffer is considered as a team builder and takes pride in academic advancement of trainees and junior faculty collaborating on the trials.  He is known for his fairness in data sharing and assisting others in developing meaningful scholarly works from study databases.  He sets high standards for relationships with the sponsors whether industry or NHLBI.

Dr. Pfeffer is Senior Associate Editor of Circulation and is a member of the Editorial Board of several other prominent journals.  He serves on the Data Safety Monitoring Boards of major international trials.  An internationally recognized expert in the field of cardiology, he was recognized by Science Watch as having the most ‘Hot Papers’ (highly cited) in all of clinical medicine.  Dr. Pfeffer was listed as one of the highly influential biomedical researchers of 1996-2011 in the European Journal of Clinical Investigation.  He is the recipient of the William Harvey Award of the American Society of Hypertension, the Okamoto Award from Japan’s Vascular Disease Research Foundation, the Clinical Research Prize, as well as, the James B. Herrick Award, both from  the American Heart Association.  Dr. Pfeffer is an Honorary Fellow of the Royal College of Physicians and Surgeons of Glasgow and is the recipient of an Honorary Doctoral Degree from Sahlgrenska Academy, University of Gothenburg, Sweden.

Cynthia Fiducia, Ed.D.

Headshot_1080 copyCynthia Fiducia, Ed.D., Instructor of Medicine, Harvard Medical School

Dr. Cynthia Fiducia received her Ed.M. in Teaching, Curriculum and Learning
Environments and her Ed.D. in Administration, Planning and Social Policy from the
Harvard Graduate School of Education. She has over thirty-five years of experience as a
professional educator across a broad range of venues. Beginning as a public high school
English teacher, and then as a curriculum director in the same setting, Dr. Fiducia next
applied her expertise as an educational consultant with a national nonprofit, followed by
her role as the executive director of an educational nonprofit collaborative, and now as
the Director of Education Programs in Clinical and Translational Science for Harvard
Catalyst.

In her current role, she oversees the planning and implementation of all
educational offerings, ensuring their integrity and assessing their effect in maximizing
adult learning in C/T research. She also coaches senior faculty course development
committees in applying effective curriculum development methods that are reflected in
integrated courses aligned with educational objectives; in using a broad pedagogical
spectrum to design learning activities that incorporate active and collaborative learning,
and social networking tools; and, in designing and using customized project management
tools for course planning and implementation. In 2013, Dr. Fiducia was appointed
Instructor in Medicine and has since applied her expertise as a consultant across Harvard
Medical School and its academic health care center affiliates to faculty interested in
designing effective outcomes-based workshops, courses, and longitudinal programs.
As the 2011 recipient of the Joseph B. Martin Dean’s Leadership Award, Harvard
Medical School acknowledged Dr. Fiducia’s work in training her staff to deliver highquality
educational offerings.

Graham T. McMahon M.D., M.M.Sc.

blackjacket2013-1Graham T. McMahon M.D., M.M.Sc.

Graham McMahon M.D., M.M.Sc. is an Associate Professor of Medicine and member of the Academy at Harvard Medical School. He is the fellowship Program Director and member of the faculty in the division of Endocrinology, Diabetes and Hypertension at Brigham & Women’s Hospital in Boston where he completed his postgraduate training. More recently, he was appointed Associate Dean for Continuing Education at Harvard Medical School. Dr. McMahon received his medical education at the Royal College of Surgeons in Ireland, a Master’s Degree in clinical research from Harvard Medical School, and his doctorate in education from the National University of Ireland.

He is also the Chief Editor for medical education at the New England Journal of Medicine and executive editor for NEJM Knowledge + a novel, adaptive and personalized learning system for physicians. Dr. McMahon is the co-director of center for expertise in medical education. Additionally, he directs the endocrinology course at Harvard Medical School and the tutorial program for “Introduction to the Profession.” Dr. McMahon has also directed a new integrated teaching unit at the Faulkner Hospital. He has received local and national awards for his teaching and his work in medical education and diabetes research. His work has been published in the New England Journal of Medicine, Diabetes Care, the Archives of Internal Medicine, the Journal of General Internal Medicine, and Medical Education. His research interests include systems of care for patients with diabetes, cardiovascular disease in diabetes, and medical education.

Stuart F. Quan, M.D.

quanphoto copyStuart F. Quan, M.D.

Dr. Quan is a graduate of the University of California, San Francisco School of Medicine. He did residency training in Internal Medicine at the University of Wisconsin, and fellowships in Critical Care Medicine and Pulmonary Medicine at the University of California, San Francisco and University of Arizona respectively. He moved to Harvard Medical School and Brigham and Women’s Hospital in 2007 where he currently is the Gerald E. McGinnis Professor of Sleep Medicine at Harvard Medical School and Senior Physician at Brigham and Women’s Hospital.

In addition, he is Professor Emeritus of Medicine at the University of Arizona where he was Chief of Pulmonary and Critical Care Medicine, Associate Head of the Department of Medicine, Program Director of the GCRC and Director of the Sleep Disorders Center. He was the founding editor-in-chief of the Journal of Clinical Sleep Medicine (2004-2014). Dr. Quan also has served as the president of the American Academy of Sleep Medicine (1999-2000), been on the board of directors of the American Board of Sleep Medicine (1990-1996). a member of the Residency Review Committee for Internal Medicine of the Accreditation Council for Graduate Medical Education; and chair of the Sleep Medicine examination committee for the American Board of Internal Medicine. Recently, he was a member of the Steering Committee that developed the new sleep scoring manual for the American Academy of Sleep Medicine and is currently the Editor of the Sleep and Health Education Program at Harvard Medical School’s Division of Sleep Medicine, Associate Editor of the Southwest Journal of Pulmonary and Critical Care and Deputy Editor of Sleep. He also is the Clinical Director of the Division of Sleep and Circadian Disorders at Brigham and Women’s Hospital.

He is the recipient of the Nathaniel Kleitman Distinguished Service and William C. Dement Academic Achievement Awards, both conferred by the American Academy of Sleep Medicine. Dr. Quan’s current research activities focus on the epidemiology of sleep and sleep disorders, particularly sleep disordered breathing.

Nancy A. Shadick, M.D., M.P.H.

nancy-shadick-2008Nancy A. Shadick, M.D., M.P.H.

Dr. Nancy A. Shadick graduated magna cum laude from Barnard College, Columbia University in 1982 and Alpha Omega Alpha from New York University School of Medicine in 1986. She trained in Internal Medicine at the Columbia Presbyterian Medical Center from 1986-1989 and in Rheumatology in our Division from 1989-1992. In 1992 she received a Masters in Public Health in Quantitative Methods from the Harvard School of Public Health. She joined the Brigham & Women’s Hospital staff and Harvard Medical School faculty when her training. In 2010, she was promoted to Associate Professor of Medicine.

Dr Shadick has a national and international reputation for clinical innovation and investigation in Rheumatoid Arthritis (RA) and Lyme disease (LD). As Director of Translational Research Development in the Division of Rheumatology, Dr Shadick founded one of the largest single center cohorts of RA in the nation; the Brigham & Women’s Hospital RA Registry (BRASS). This Registry of over 1300 subjects followed yearly has contributed to expanding our knowledge of integral biomarkers of disease response. 9see www.brassstudy.org).She teaches in the clinic and her lab and also directs the PACO and PARASS Initiatives for RA patient education. Dr Shadick’s clinical practice consists of referrals with severe RA and Lyme Arthritis. She teaches Rheumatology to students, residents and fellows on the wards and clinic. Her research has received peer reviewed funding by the NIH, CDC, foundation and pharmaceutical grants and she served on many review and professional organization committees.

Dr. Shadick’s clinical innovation relates to 1) the first description, using population-based methodology, of the phenomenon of incomplete recovery from LD leading to a change in treatment recommendations and earlier diagnosis and 2) development of a novel educational program that was the first to result in a reduction in LD cases. In the area of RA, her work has delineated clinical and genetic risk factors for disease severity and inflammatory risk factors for RA incidence. Early in her training she described a novel comorbidity in RA; bronchiectasis. Most recently her clinical innovation is in developing programs that realign care towards the patient perspective on RA patient education and self management initiatives in the R.B. Brigham Arthritis Center

Dr Shadick has provided significant service to the Community in her public health work on Lyme Disease prevention and RA. In LD, with funding from the CDC and the Mass. Dept. of Public Health she has devoted 15 years to educating the public about LD prevention. Her work has been disseminated to over 50,000 residents of the Islands of Martha’s Vineyard, Nantucket and the North Shore of MA. She has given numerous talks to the public about LD recovery and prevention via radio addresses and public service announcements and contributed to local community newsletters, and town meetings. Dr Shadick has also served on the State’s Task Force for Tick-Borne disease control. She developed the first educational program to result in a 40% reduction in LD due to an increase in tick bite precautionary behavior and this novel program became curriculum in the North Shore school system of MA. Dr Shadick consults on LD prevention throughout the state and her work has been incorporated into the Mass Dept of Public Health and CDC sponsored programs that have been disseminated throughout the U.S. (see www.bwhpreventlyme.org).

As Director of the PACO (Patient Centered Outcomes) and PARASS (Patient RA Social Support) studies, Dr. Shadick has developed educational programs and materials that improve the lives of RA patients. She has designed and organized educational seminars and materials, spearheaded the development of a patient advisory committee, new communication tools (Health Log©) and created the “Living Well with RA©” program a self help intervention that has improved clinical outcomes(see www.pacostudy.org).. The PARASS study supports a successful peer support program with over 200 peer counseling matches, and a video-journaling program(www.parassstudy.org). She has presented nationally at the Annual Scientific Conference about the programs, has written invited reviews, disseminated her educational materials and websites and given many lay presentations to patients about RA treatment from the patient perspective. She maintains an active newsletter available to over 1500 RA patients.

Dr. Shadick’s innovative work on the diagnosis, treatment and prevention of LD and RA has earned her national recognition as an independent clinical expert. As a testament to the respect by her peers for her clinical expertise, Dr. Shadick has been elected “America’s Top Doctors” since 2001 and “Best of Boston” since 2008.

Naomi D.L. Fisher, M.D.

head 14Naomi DL Fisher, M.D., Associate Professor of Medicine, Harvard Medical School

Dr. Naomi Fisher received her Bachelor of Arts degree in the History and Philosophy of Science from Princeton University, magna cum laude, and her medical degree from the University of Pennsylvania.  She completed her internship and residency in internal medicine at the Massachusetts General Hospital.  She finished a clinical fellowship in Endocrinology, Diabetes and Hypertension as well as a research fellowship in Hypertension at the Brigham and Women’s Hospital, and has been on staff at the BWH ever since.

Dr. Fisher has completed over two decades of clinical research at Harvard University, focusing on cardiovascular endocrinology. She has conducted dozens of clinical trials at the Brigham and Women’s Hospital’s Clinical Research Center, having served as Principal Investigator on studies funded both by industry and the NIH with over 20 years of continuous NIH funding.  Her areas of research expertise include hypertension and diabetes; vascular regulation; aging; cognition; endothelial function; genetics; and flavanols.  She is the author of over 50 peer-reviewed original research publications in high impact medical journals, including Circulation, Neurology and Hypertension.  Dr. Fisher’s bibliography includes not only original scientific reports, but standards of care, clinical guidelines, reviews, chapters and online resources. She has served as Reviewer for multiple NIH Clinical Trials Panels and for many journals, as well as for the Institutional Review Board of the Brigham and Women’s Hospital.

Clinically, Dr. Fisher is founder and Director of Hypertension Services and the Hypertension Specialty Clinic at the Brigham and Women’s Hospital.  As an endocrinologist she is repeatedly cited in multiple Best Doctors listings. She serves as clinical expert in Hypertension for the Massachusetts Department of Public Health Prevention and Wellness Trust Fund protocols.

Dr. Fisher is a veteran teacher, currently serving as Director for the Harvard Catalyst Design of Clinical Trials course. She directs the monthly Harvard Hypertension Conference and is invited regularly to teach house staff, fellows, primary care doctors and specialists about clinical issues and research. She served as co-director and lecturer for the HMS Pasteur Society Research Program for first year medical students for seven years.  She also served on the selection committee and as advisor for the Doris Duke Foundation Clinical Research Fellowship Program.  She has delivered lectures on local, national and international levels, in live venues and on radio and television. In addition to medical topics, she teaches about effective written and oral communication.

Dan L. Longo, M.D.

Dan LongoDan L. Longo, M.D., M.A.C.P., Professor of Medicine, Harvard Medical School

Dr. Dan L. Longo received his A.B. degree from Washington University in St. Louis and his M.D. cum laude from the University of Missouri. He completed training in Internal Medicine at the Peter Bent Brigham Hospital and Harvard Medical School in Boston. His fellowship in Oncology and Hematology was completed at the National Cancer Institute (NCI) of the National Institutes of Health (NIH) in Bethesda, Maryland. Following his clinical training, he did post-doctoral laboratory training in the Laboratory of Immunology (William Paul, Chief) of the National Institute of Allergy and Infectious Diseases, NIH. In 1980, he became a Senior Investigator (tenured) in the Medicine Branch of the NCI and in 1985, he became the Director of the NCI’s Biological Response Modifiers Program. In 1995, he became Scientific Director at the National Institute on Aging and remained there until 2010.

After 33 years at the NIH, he returned to Boston in 2010 as Senior Physician in the Division of Hematology, Department of Medicine at Brigham and Women’s Hospital and Professor of Medicine, Harvard Medical School and became Deputy Editor of the New England Journal of Medicine.

He has published nearly 900 peer-reviewed papers, review articles, editorials, and book chapters and has been an editor of Harrison’s Principles of Internal Medicine since 1994, including serving as Editor-in-Chief of the 18th edition. He has written or edited 25 books.

His major research interest has been T- and B-cell development and the control of normal and malignant lymphocyte proliferation. He and his colleagues identified key cell interactions in T-cell development, demonstrated the influence of positive and negative selection on both B-cell and T-cell repertoires, and showed the stimulatory effects of certain hormones on thymic function. His group demonstrated that signals delivered through cell surface receptors associated with the activation of normal lymphocytes could kill or irreversibly growth-inhibit malignant lymphocytes. Thus, immunoglobulin receptors, class II MHC molecules, and CD40 were identified as targets for therapy of B-cell lymphomas and T-cell antigen receptors and CD30 were identified as targets for therapy of T cell lymphomas. All of these targets are being tested for clinical efficacy.

His group identified a specific form of immune suppression associated with the tumor-bearing state and applied the findings to adoptive immunotherapy studies in man. They also described an important subtype of lymphoma and developed new therapies for Hodgkin’s disease and lymphoma that are safer and more effective. His group was the first to immunize a normal bone marrow donor against the host’s tumor and transfer tumor-specific immunity to the host.

He has been listed in every edition of Best Doctors in America. He is in the top 1% of cited authors in life sciences. His awards include the NIH Merit Award, the NIH Director’s Award (twice), outstanding service medals and unit commendations from the US Public Health Service, and the Tovi Comet-Walerstein Award.